Miller was born in Memphis, Tennessee and raised in St. Louis. She received her BFA in painting from Washington University in St. Louis in 1977, and studied at Temple University in Philadelphia. She taught design at St. Louis Community College and was a painting instructor at Beaver College, as well as a guest lecturer at institutions such as Webster University, Cornell University Rome, and Temple University Rome. Miller has been featured in over 49 individual and collective exhibitions in cities around the world, including New York, Kansas City, Chicago, Italy, Switzerland and Taipei, and her work is held in private collections across the United States and Europe.